Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complement factor H polymorphism and age-related macular degeneration.

Science (New York, N.Y.) - 15 Apr 2005

Edwards Albert O, Ritter Robert, Abel Kenneth J, Manning Alisa, Panhuysen Carolien, Farrer Lindsay A

Abstract excerpt

Age-related macular degeneration (AMD) is a common, late-onset, and complex trait with multiple risk factors. Concentrating on a region harboring a locus for AMD on 1q25-31, the ARMD1 locus, we tested single-nucleotide polymorphisms for association with AMD in two independent case-control populations. Significant association (P = 4.95 x 10(-10)) was identified within the regulation of complement activation locus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Chromosomes, Human, Pair 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement Activation

Share to Complement Factor H

Share to Histidine

Share to Macular Degeneration

Share to Multigene Family

Share to Tyrosine

Source

Identifiers

PMID: 15761121
DOI: 10.1126/science.1110189

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complement factor H polymorphism and age-related macular degeneration.PMID 15761121Read ↗

Complement factor H variant increases the risk of age-related macular degeneration.Semantic proximity Read ↗

Complement factor H polymorphism in age-related macular degeneration.Semantic proximity Read ↗

Role of genetic factors and inflammation in age-related macular degeneration.Semantic proximity Read ↗

Complement Factor H Polymorphism, Complement Activators, and Risk of Age-Related Macular DegenerationSemantic proximity Read ↗

Genetic Insights into Age-Related Macular DegenerationSemantic proximity Read ↗

Unraveling a complex genetic disease: age-related macular degeneration.Semantic proximity Read ↗

Complement factor H in AMD: Bridging genetic associations and pathobiology.Semantic proximity Read ↗

Genetic Factors Associated with Age-Related Macular DegenerationSemantic proximity Read ↗

The molecular genetic basis of age-related macular degeneration: an overview.Semantic proximity Read ↗

Multilocus analysis of age-related macular degeneration.Semantic proximity Read ↗

Systematic review and meta-analysis of the association between complement factor H Y402H polymorphisms and age-related macular degeneration.Semantic proximity Read ↗

Age-related macular degeneration: genetics and biology coming together.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.