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Article

Abnormal spermatogenesis in RXR beta mutant mice.

Genes & development - 1 Jan 1996

Kastner P, Mark M, Leid M, Gansmuller A, Chin W, Grondona J M, Décimo D, Krezel W, Dierich A, Chambon P

Abstract excerpt

We have generated mouse lines in which the RXR beta gene was disrupted by homologous recombination. Approximately 50% of the RXR beta homozygous mutants died before or at birth, but those that survived appeared normal except that the males were sterile, owing to oligo-astheno-teratozoospermia. Failure of spermatid release occurred within the germinal epithelium, and the epididymis contained very few spermatozoa...

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Source

Identifiers

PMID: 8557197
DOI: 10.1101/gad.10.1.80

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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