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Article

Hormone-sensitive lipase deficiency alters gene expression and cholesterol content of mouse testis.

Reproduction (Cambridge, England) - 1 Feb 2017

Wang Feng, Chen Zheng, Ren Xiaofang, Tian Ye, Wang Fucheng, Liu Chao, Jin Pengcheng, Li Zongyue, Zhang Feixiong, Zhu Baochang

Abstract excerpt

Hormone-sensitive lipase-knockout (HSL-/-) mice exhibit azoospermia for unclear reasons. To explore the basis of sterility, we performed the following three experiments. First, HSL protein distribution in the testis was determined. Next, transcriptome analyses were performed on the testes of three experimental groups. Finally, the fatty acid and cholesterol levels in the testes with three different genotypes...

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Source

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Identifiers

PMID: 27920259
DOI: 10.1530/REP-16-0484
PMCID: PMC5148802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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