Article
Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.
Molecular and cellular biology - 1 Jun 2000
Wan Y J, An D, Cai Y, Repa J J, Hung-Po Chen T, Flores M, Postic C, Magnuson M A, Chen J, Chien K R, French S, Mangelsdorf D J, Sucov H M
Abstract excerpt
A large number of physiological processes in the adult liver are regulated by nuclear receptors that require heterodimerization with retinoid X receptors (RXRs). In this study, we have used cre-mediated recombination to disrupt the mouse RXRalpha gene specifically in hepatocytes. Although such mice are viable, molecular and biochemical parameters indicate that every one of the examined metabolic pathways in the...
Topics
- Animals
- Homeostasis
- Liver
- Mice
- Mutation
- Receptors, Retinoic Acid
- Retinoid X Receptors
- Signal Transduction
- Transcription Factors