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Article

Calpastatin overexpression in the skeletal muscle of mice prevents clenbuterol-induced muscle hypertrophy and phenotypic shift.

Clinical and experimental pharmacology & physiology - 1 Apr 2012

Douillard Aymeric, Galbes Olivier, Begue Gwenaelle, Rossano Bernadette, Levin John, Vernus Barbara, Bonnieu Anne, Candau Robin, Py Guillaume

Abstract excerpt

Accumulating evidence suggests that the calpain/calpastatin system is involved in skeletal muscle remodelling induced by β(2) -adrenoceptor agonist treatment. In addition to other pathways, the Akt/mammalian target of rapamycin (mTOR) pathway, controlling protein synthesis, and the calcium/calmodulin-dependent protein kinase 2 (CamK2) and AMP-activated protein kinase (AMPK) pathways, recently identified as...

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PMID: 22300302
DOI: 10.1111/j.1440-1681.2012.05677.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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