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Article

Rf-2 Gene Modulates Proteinuria and Albuminuria Independently of Changes in Glomerular Permeability in the Fawn-Hooded Hypertensive Rat

9 Mar 2005

Abstract excerpt

We report that Rab38, a gene within the Rf-2 locus appears to influence the development of proteinuria (UPV) and albuminuria (UAV) in fawn-hooded hypertensive rats (FHH). Using congenic animals, we narrowed the region to eight genes; however, only one gene had a sequence variant. Rab38 has a mutation in the start codon, resulting in a natural knockout in the FHH strain. Despite no differences in glomerular...

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PMID: 15758045
DOI: 10.1681/asn.2005010029

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