Article
A 4.1-Mb congenic region of Rf-4 contributes to glomerular permeability.
Journal of the American Society of Nephrology : JASN - 1 May 2012
O'Meara Caitlin C, Lutz Michelle M, Sarkis Allison B, Xu Haiyan, Kothinti Rajendra K, Hoffman Matthew, Moreno Carol, Tabatabai Niloofar M, Lazar Jozef, Roman Richard J, Jacob Howard J
Abstract excerpt
The combined transfer of two renal function quantitative trait loci (QTLs), Rf-1 (rat chromosome 1) and Rf-4 (rat chromosome 14), from the Fawn-hooded hypertensive rat onto the August Copenhagen Irish genetic background significantly increases proteinuria and demonstrates an interaction between these QTLs. Because the original Rf-4 congenic region is 61.9 Mbp, it is necessary to reduce this interval to feasibly...
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