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Article

Role of genetic modifiers in an orthologous rat model of ARPKD.

Physiological genomics - 1 Aug 2012

O'Meara Caitlin C, Hoffman Matthew, Sweeney William E, Tsaih Shirng-Wern, Xiao Bing, Jacob Howard J, Avner Ellis D, Moreno Carol

Abstract excerpt

Human data and animal models of autosomal recessive polycystic kidney disease (ARPKD) suggest that genetic factors modulate the onset and severity of the disease. We report here for the first time that ARPKD susceptibility is attenuated by introgressing the mutated Pkhd1 disease allele from the polycystic kidney (PCK) rat onto the FHH (Fawn-Hooded Hypertensive) genetic background. Compared with PCK, the FHH.Pkhd1...

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Identifiers

PMID: 22669842
DOI: 10.1152/physiolgenomics.00187.2011
PMCID: PMC3774585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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