Article
Renal damage susceptibility and autoregulation in RF-1 and RF-5 congenic rats.
Nephron. Experimental nephrology - 1 Jan 2005
Van Dijk Sabine J, Specht Patricia A C, Lazar Jozef, Jacob Howard J, Provoost Abraham P
Abstract excerpt
BACKGROUND: Linkage analyses of crosses of rats susceptible to renal damage, fawn-hooded hypertensive (FHH), and those resistant to kidney damage, August x Copenhagen Irish (ACI), indicated that five quantitative trait loci (QTLs), Rf-1 to Rf-5, influence proteinuria (UPV), albuminuria (UAV) and focal glomerulosclerosis (FGS). Here we present data obtained in congenic rats to directly assess the role of the Rf-1...
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