Article
Twin study of genetic and aging effects on X chromosome inactivation.
European journal of human genetics : EJHG - 1 May 2005
Kristiansen Marianne, Knudsen Gun P S, Bathum Lise, Naumova Anna K, Sørensen Thorkild I A, Brix Thomas H, Svendsen Anders J, Christensen Kaare, Kyvik Kirsten O, Ørstavik Karen H
Abstract excerpt
To investigate the genetic influence on X chromosome inactivation and on age-related skewing of X inactivation, in particular, we analysed the X inactivation pattern (XIP) in peripheral blood cells from 118 young monozygotic (MZ) twin pairs (18-53 years), 82 elderly MZ twin pairs (55-94 years), 146 young dizygotic (DZ) twin pairs (20-54 years) and 112 elderly DZ twin pairs (64-95 years). Elderly twins had a...
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