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Article

Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant.

Journal of cell science - 1 Apr 2005

Georgiev Plamen, Garcia-Murillas Isaac, Ulahannan Danny, Hardie Roger C, Raghu Padinjat

Abstract excerpt

The TRP family of ion channels mediates a wide range of calcium-influx phenomena in eukaryotic cells. Many members of this family are activated downstream of phosphoinositide hydrolysis but the subsequent steps that lead to TRP channel activation in vivo remain unclear. Recently, the lipid products of phosphoinositide hydrolysis (such as diacylglycerol and its metabolites) have been implicated in activating TRP...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15755798
DOI: 10.1242/jcs.01712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant.PMID 15755798Read ↗

TRP channels in Drosophila photoreceptors: the lipid connection.Semantic proximity Read ↗

Constitutive activity of the light-sensitive channels TRP and TRPL in the Drosophila diacylglycerol kinase mutant, rdgA.Semantic proximity Read ↗

A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade.Semantic proximity Read ↗

Exploring Excitotoxicity and Regulation of a Constitutively Active TRP Ca2+ Channel in Drosophila.Semantic proximity Read ↗

Phospholipase C and termination of G-protein-mediated signalling in vivo.Semantic proximity Read ↗

Identification of a suppressor of retinal degeneration in Drosophila photoreceptors.Semantic proximity Read ↗

Regulation of phototransduction responsiveness and retinal degeneration by a phospholipase D-generated signaling lipid.Semantic proximity Read ↗

Regulation of PLC-mediated signalling in vivo by CDP-diacylglycerol synthase.Semantic proximity Read ↗

Independent anchoring and assembly mechanisms of INAD signaling complexes in Drosophila photoreceptors.Semantic proximity Read ↗

Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex.Semantic proximity Read ↗

Mammalian homolog of Drosophila retinal degeneration B rescues the mutant fly phenotype.Semantic proximity Read ↗

A forward genetic screen in Drosophila melanogaster to identify mutations affecting INAD localization in photoreceptor cells.Semantic proximity Read ↗

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