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Article

Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex.

Neuron - 1 Jan 1997

Chevesich J, Kreuz A J, Montell C

Abstract excerpt

In Drosophila, the store-operated Ca2+ channel, TRP, is required in photoreceptor cells for a sustained response to light. Here, we show that TRP forms a complex with phospholipase C-beta (NORPA), rhodopsin (RH1), calmodulin, and the PDZ domain containing protein INAD. Proteins with PDZ domains h...

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Source

Identifiers

PMID: 9010208
DOI: 10.1016/s0896-6273(01)80049-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9010208-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex.PMID 9010208Read ↗

The PDZ scaffold protein INAD abolishes apparent store-dependent regulation of the light-activated cation channel TRP.Semantic proximity Read ↗

A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade.Semantic proximity Read ↗

A forward genetic screen in Drosophila melanogaster to identify mutations affecting INAD localization in photoreceptor cells.Semantic proximity Read ↗

Independent anchoring and assembly mechanisms of INAD signaling complexes in Drosophila photoreceptors.Semantic proximity Read ↗

The Calliphora rpa mutant lacks the PDZ domain-assembled INAD signalling complex.Semantic proximity Read ↗

New light on TRP and TRPL.Semantic proximity Read ↗

Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel.Semantic proximity Read ↗

The roles of trp and calcium in regulating photoreceptor function in Drosophila.Semantic proximity Read ↗

Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant.Semantic proximity Read ↗

Assembly of the Drosophila phototransduction cascade into a signalling complex shapes elementary responses.Semantic proximity Read ↗

Phosphoinositide-mediated phototransduction in Drosophila photoreceptors: the role of Ca2+ and trp.Semantic proximity Read ↗

Interaction of eye protein kinase C and INAD in Drosophila. Localization of binding domains and electrophysiological characterization of a loss of association in transgenic flies.Semantic proximity Read ↗

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