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Article

A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade.

Nature - 17 Jul 1997

Tsunoda S, Sierralta J, Sun Y, Bodner R, Suzuki E, Becker A, Socolich M, Zuker C S

Abstract excerpt

How are signalling molecules organized into different pathways within the same cell? In Drosophila, the inaD gene encodes a protein consisting of five PDZ domains which serves as a scaffold to assemble different components of the phototransduction cascade, including the principal light-activated...

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PMID: 9230432
DOI: 10.1038/40805

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9230432-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade.PMID 9230432Read ↗

Assembly of the Drosophila phototransduction cascade into a signalling complex shapes elementary responses.Semantic proximity Read ↗

Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex.Semantic proximity Read ↗

Independent anchoring and assembly mechanisms of INAD signaling complexes in Drosophila photoreceptors.Semantic proximity Read ↗

Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant.Semantic proximity Read ↗

A forward genetic screen in Drosophila melanogaster to identify mutations affecting INAD localization in photoreceptor cells.Semantic proximity Read ↗

The Calliphora rpa mutant lacks the PDZ domain-assembled INAD signalling complex.Semantic proximity Read ↗

Light-dependent phosphorylation of the Drosophila inactivation no afterpotential D (INAD) scaffolding protein at Thr170 and Ser174 by eye-specific protein kinase C.Semantic proximity Read ↗

Phospholipase C and termination of G-protein-mediated signalling in vivo.Semantic proximity Read ↗

Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD.Semantic proximity Read ↗

The PDZ scaffold protein INAD abolishes apparent store-dependent regulation of the light-activated cation channel TRP.Semantic proximity Read ↗

Interaction of eye protein kinase C and INAD in Drosophila. Localization of binding domains and electrophysiological characterization of a loss of association in transgenic flies.Semantic proximity Read ↗

Unraveling the genetic complexity of Drosophila stardust during photoreceptor morphogenesis and prevention of light-induced degeneration.Semantic proximity Read ↗

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