Article
Phospholipase C and termination of G-protein-mediated signalling in vivo.
Nature cell biology - 1 May 2000
Cook B, Bar-Yaacov M, Cohen Ben-Ami H, Goldstein R E, Paroush Z, Selinger Z, Minke B
Abstract excerpt
In Drosophila photoreceptors, phospholipase C (PLC) and other signalling components form multiprotein structures through the PDZ scaffold protein INAD. Association between PLC and INAD is important for termination of responses to light; the underlying mechanism is, however, unclear. Here we report that the maintenance of large amounts of PLC in the signalling membranes by association with INAD facilitates...
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