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Article

Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo.

The Journal of biological chemistry - 13 May 2005

Maeda Akiko, Maeda Tadao, Imanishi Yoshikazu, Kuksa Vladimir, Alekseev Andrei, Bronson J Darin, Zhang Houbin, Zhu Li, Sun Wenyu, Saperstein David A, Rieke Fred, Baehr Wolfgang, Palczewski Krzysztof

Abstract excerpt

The retinoid cycle is a recycling system that replenishes the 11-cis-retinal chromophore of rhodopsin and cone pigments. Photoreceptor-specific retinol dehydrogenase (prRDH) catalyzes reduction of all-trans-retinal to all-trans-retinol and is thought to be a key enzyme in the retinoid cycle. We disrupted mouse prRDH (human gene symbol RDH8) gene expression by targeted recombination and generated a homozygous...

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Identifiers

PMID: 15755727
DOI: 10.1074/jbc.M501757200
PMCID: PMC1283069

Genes

RDH8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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