Article
Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice.
The Journal of biological chemistry - 8 Dec 2006
Maeda Akiko, Maeda Tadao, Imanishi Yoshikazu, Sun Wenyu, Jastrzebska Beata, Hatala Denise A, Winkens Huub J, Hofmann Klaus Peter, Janssen Jacques J, Baehr Wolfgang, Driessen Carola A, Palczewski Krzysztof
Abstract excerpt
RDH12 has been suggested to be one of the retinol dehydrogenases (RDH) involved in the vitamin A recycling system (visual cycle) in the eye. Loss of function mutations in the RDH12 gene were recently reported to be associated with autosomal recessive childhood-onset severe retinal dystrophy. Here we show that RDH12 localizes to the photoreceptor inner segments and that deletion of this gene in mice slows the...
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