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Article

Targeted Disruption of the Murine Retinal Dehydrogenase Gene <i>Rdh12</i> Does Not Limit Visual Cycle Function

28 Nov 2006

Abstract excerpt

RDH12 codes for a member of the family of short-chain alcohol dehydrogenases/reductases proposed to function in the visual cycle that supplies the chromophore 11-cis retinal to photoreceptor cells. Mutations in RDH12 cause severe and progressive childhood onset autosomal-recessive retinal dystrophy, including Leber congenital amaurosis. We generated Rdh12 knockout mice, which exhibited grossly normal retinal...

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PMID: 17130236
DOI: 10.1128/mcb.01486-06

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Source receipt: pubmed, retrieved 7 Sept 2026.

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