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Article

Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man.

Visual neuroscience - 1 Jan 2000

Cideciyan Artur V, Haeseleer Françoise, Fariss Robert N, Aleman Tomas S, Jang Geeng-Fu, Verlinde Christophe L M J, Marmor Michael F, Jacobson Samuel G, Palczewski Krzysztof

Abstract excerpt

Vertebrate vision starts with photoisomerization of the 11-cis-retinal chromophore to all-trans-retinal. Biosynthesis of 11-cis-retinal is required to maintain vision. A key enzyme catalyzing the oxidation of 11-cis-retinol is 11-cis-retinol dehydrogenase (11-cis-RDH), which is encoded by the RDH5 gene. 11-cis-RDH is expressed in the RPE and not in the neural retina. The consequences of a lack of 11-cis-RDH were...

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Source

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Identifiers

PMID: 11153648
DOI: 10.1017/s0952523800175029
PMCID: PMC1410813

Genes

RDH5
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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