Article
Different mutations of the RET gene cause different human tumoral diseases.
Biochimie - 1 Apr 1999
Santoro M, Melillo R M, Carlomagno F, Visconti R, De Vita G, Salvatore G, Fusco A, Vecchio G
Abstract excerpt
The RET gene encodes a tyrosine kinase receptor for neurotrophic molecules. RET is a conceptually valuable example of how different mutations of a single gene may cause different diseases. Gene rearrangements activate the oncogenic potential of RET in human thyroid papillary carcinomas. On the other side, different point mutations activate RET in familial multiple endocrine neoplasia syndromes. Finally,...
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