Article
Ras/ERK1/2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation.
The Journal of biological chemistry - 2 Mar 2007
Plaza-Menacho Iván, van der Sluis Tineke, Hollema Harry, Gimm Oliver, Buys Charles H C M, Magee Anthony I, Isacke Clare M, Hofstra Robert M W, Eggen Bart J L
Abstract excerpt
The precise role of STAT3 Ser(727) phosphorylation in RET-mediated cell transformation and oncogenesis is not well understood. In this study, we have shown that familial medullary thyroid carcinoma (FMTC) mutants RET(Y791F) and RET(S891A) induced, in addition to Tyr(705) phosphorylation, constitutive STAT3 Ser(727) phosphorylation. Using inhibitors and dominant negative constructs, we have demonstrated that...
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