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Article

Structural bases of unphosphorylated STAT1 association and receptor binding.

Molecular cell - 18 Mar 2005

Mao Xiang, Ren Zhiyong, Parker Gregory N, Sondermann Holger, Pastorello Michael A, Wang Wei, McMurray John S, Demeler Borries, Darnell James E, Chen Xiaomin

Abstract excerpt

The crystal structure has been determined at 3.0 A resolution for an unphosphorylated STAT1 (1-683) complexed with a phosphopeptide derived from the alpha chain of interferon gamma (IFNgamma) receptor. Two dimer interfaces are seen, one between the N domains (NDs) (amino acid residues 1-123) and the other between the core fragments (CFs) (residues 132-683). Analyses of the wild-type (wt) and mutant STAT1 proteins...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15780933
DOI: 10.1016/j.molcel.2005.02.021

Genes

STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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