Article
A reinterpretation of the dimerization interface of the N-terminal domains of STATs.
Protein science : a publication of the Protein Society - 1 Feb 2003
Chen Xiaomin, Bhandari Rashna, Vinkemeier Uwe, Van Den Akker Focco, Darnell James E, Kuriyan John
Abstract excerpt
The crystal structures of the N-terminal domain (N-domain) and the core region of the STAT family of transcription factors have been determined previously. STATs can form cooperative higher order structures (tetramers or higher oligomers) while bound to DNA. The crystal packing in the STAT4 N-domain crystal structure, determined at 1.5 A resolution, suggests two alternate organizations of the N-domain dimer. We...
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