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Article

Structural basis of STAT2 recognition by IRF9 reveals molecular insights into ISGF3 function

9 Jan 2018

Abstract excerpt

Cytokine signaling through the JAK/STAT pathway controls multiple cellular responses including growth, survival, differentiation, and pathogen resistance. An expansion in the gene regulatory repertoire controlled by JAK/STAT signaling occurs through the interaction of STATs with IRF transcription factors to form ISGF3, a complex that contains STAT1, STAT2, and IRF9 and regulates expression of IFN-stimulated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29317535
DOI: 10.1073/pnas.1718426115

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