Article
N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation.
Nature immunology - 1 Feb 2004
Ota Naruhisa, Brett Tom J, Murphy Theresa L, Fremont Daved H, Murphy Kenneth M
Abstract excerpt
The N-terminal protein interaction domain (N-domain) of the signal transducer and activator of transcription-4 (STAT4) is believed to stabilize interactions between two phosphorylated STAT4 dimers to form STAT4 tetramers. Here, we show that nonphosphorylated STAT4 dimers form in vivo before cytokine receptor-driven activation. Mutations in the N-domain dimerization interface abolished assembly of...
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