Article
Will we be able to 'spot' an effective HIV-1 vaccine?
Trends in immunology - 1 Feb 2003
Yang Otto O
Abstract excerpt
Many HIV-1 vaccine efforts have heavily emphasized class I-restricted CD8(+) cytotoxic T lymphocytes (CTLs) as a potentially important arm of immunity. Commonly used CTL assays describe only specificity and frequency, and not antiviral effects. However, increasing evidence indicates that CTL antiviral function is determined by the complex interplay of multiple virologic and cellular factors, and thus these...
Topics
- AIDS Vaccines
- HIV Infections
- HIV-1
- Humans
- Mutation
- T-Lymphocytes, Cytotoxic
- Virus Replication