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Article

Histone acetyltransferase p300 promotes the activation of human WT1 promoter and intronic enhancer.

Archives of biochemistry and biophysics - 1 Apr 2005

Shao Yangguang, Lu Jun, Zhang Guoping, Liu Chunyan, Huang Baiqu

Abstract excerpt

The Wilms' tumor gene-1 (WT1) encodes a zinc finger protein involved in gene regulation during kidney, gonad, and heart development. In addition to its promoter, a 258 bp intronic enhancer is required for tissue-specific expression of WT1 gene. p300 is a histone acetyltransferase (HAT) and exerts essential functions in gene regulation. Here, we show that p300 increased the expression of endogenous WT1 mRNA and...

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Identifiers

PMID: 15752709
DOI: 10.1016/j.abb.2005.01.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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