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Article

AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.

The Journal of biological chemistry - 9 Apr 2004

Yamaguchi Yuko, Kurokawa Mineo, Imai Yoichi, Izutsu Koji, Asai Takashi, Ichikawa Motoshi, Yamamoto Go, Nitta Eriko, Yamagata Tetsuya, Sasaki Kazuki, Mitani Kinuko, Ogawa Seishi, Chiba Shigeru, Hirai Hisamaru

Abstract excerpt

AML1 (RUNX1) is one of the most frequently disrupted genes in human leukemias. AML1 encodes transcription factors, which play a pivotal role in hematopoietic differentiation, and their inappropriate expression is associated with leukemic transformation of hematopoietic cells. Previous studies demonstrated that the transcription cofactor p300 binds to the C-terminal region of AML1 and stimulates AML1-dependent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14752096
DOI: 10.1074/jbc.M400355200

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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