Enhanced susceptibility to chemical induction of ovarian tumors in mice with a germ line p53 mutation.

Abstract excerpt

Mice with a germ line p53 mutation (p53(Ala135Val/wt)) display increased susceptibility to lung, skin, and colon carcinogenesis. Here, we show that p53(Ala135Val/wt) mice developed ovarian tumors significantly more rapidly than their wild-type littermates after 7,12-dimethylbenz(a)anthracene (DMBA) treatment. Approximately 50% of the ovarian tumors in p53(wt/wt) mice and 23% in p53(Ala135Val/wt) mice are...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to 9,10-Dimethyl-1,2-benzanthracene
• Share to Gene Expression Regulation, Neoplastic