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Article

BCR-ABL: a multi-faceted promoter of DNA mutation in chronic myelogeneous leukemia.

Leukemia - 1 Jun 2010

Burke B A, Carroll M

Abstract excerpt

The role of the BCR-ABL oncogene in the progression of chronic myeloid leukemia (CML) to blast crisis (BC) is unknown. The appearance of chromosomal aberrations in patients with CML BC has led to many attempts to elucidate a mechanism whereby BCR-ABL affects DNA damage and repair. BCR-ABL-expressing cells have been found to accumulate genetic abnormalities, but the mechanism leading to this genomic instability is...

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Share to DNA Damage
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fusion Proteins, bcr-abl

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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Share to Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 20445577
DOI: 10.1038/leu.2010.67
PMCID: PMC4425294

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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