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Article

Bloom syndrome, genomic instability and cancer: the SOS-like hypothesis.

Cancer letters - 8 May 2006

Amor-Guéret Mounira

Abstract excerpt

Bloom syndrome (BS) displays one of the strongest known correlations between chromosomal instability and an increased risk of malignancy at an early age. The prevention of genomic instability and cancer depends on a complex network of pathways induced in response to DNA damage and stalled replication forks, including cell-cycle checkpoints, DNA repair, and apoptosis. Several studies have demonstrated that BLM is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15950375
DOI: 10.1016/j.canlet.2005.04.023

Genes

BLM
RAD51

Provenance

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