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Article

Deficiency of Bloom syndrome helicase activity is radiomimetic.

Cancer biology & therapy - 1 Nov 2008

Horowitz David P, Topaloglu Ozlem, Zhang Yonggang, Bunz Fred

Abstract excerpt

Bloom syndrome is caused by homozygous mutations in BLM, which encodes a RecQ DNA helicase. Patient-derived cells deficient in BLM helicase activity exhibit genetic instability--apparent cytogenetically as sister chromatid exchanges--and activated DNA damage signaling. In this report, we show that BLM-knockout colorectal cancer cells exhibited endogenous, ATM-dependent double-strand DNA break responses similar to...

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Source

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Identifiers

PMID: 18787401
DOI: 10.4161/cbt.7.11.6779
PMCID: PMC2891340

Genes

BLM
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Deficiency of Bloom syndrome helicase activity is radiomimetic.PMID 18787401Read ↗

Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes.Semantic proximity Read ↗

BLM helicase is activated in BCR/ABL leukemia cells to modulate responses to cisplatin.Semantic proximity Read ↗

Bloom helicase and DNA topoisomerase IIIalpha are involved in the dissolution of sister chromatids.Semantic proximity Read ↗

Bloom helicase is involved in DNA surveillance in early S phase in vertebrate cells.Semantic proximity Read ↗

Genomic instability and cancer: lessons from analysis of Bloom's syndrome.Semantic proximity Read ↗

Palliative chemotherapy is well tolerated in a patient with metastatic colorectal cancer due to Bloom syndrome with a novel BLM mutationSemantic proximity Read ↗

Enhanced tumor formation in mice heterozygous for Blm mutation.Semantic proximity Read ↗

BLM helicase determines chemotherapy-induced responses of human glioma cells and shifts between apoptosis, senescence or polyploidySemantic proximity Read ↗

The Human WRN and BLM RecQ Helicases Differentially Regulate Cell Proliferation and Survival after Chemotherapeutic DNA DamageSemantic proximity Read ↗

A case of Bloom syndrome manifesting with therapy-related myelodysplastic syndromes harboring a novel BLM gene variant.Semantic proximity Read ↗

Mutation of the murine Bloom's syndrome gene produces global genome destabilization.Semantic proximity Read ↗

BLM helicase overexpressed in human gliomas contributes to diverse responses of human glioma cells to chemotherapySemantic proximity Read ↗

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