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Article

Human acid ceramidase is overexpressed but not mutated in prostate cancer.

Genes, chromosomes & cancer - 1 Oct 2000

Seelan R S, Qian C, Yokomizo A, Bostwick D G, Smith D I, Liu W

Abstract excerpt

The human acid ceramidase gene, that causes Farber disease, is located in 8p22, a region frequently altered in several cancers, including prostate cancer. Acid ceramidase catalyzes the hydrolysis of ceramide, a potent lipid second messenger molecule that promotes apoptosis and inhibits cellular proliferation. It is not known whether this gene, or its expression, is altered in prostate cancer. Here, we report the...

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PMID: 10959093
DOI: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1018>3.0.co;2-e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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