Article
Germline ATBF1 mutations and prostate cancer risk.
The Prostate - 1 Jul 2006
Xu Junyan, Sauvageot Jurga, Ewing Charles M, Sun Jielin, Liu Wennuan, Isaacs Sarah D, Wiley Kathleen E, Diaz Lina, Zheng S Lilly, Walsh Patrick C, Isaacs William B
Abstract excerpt
BACKGROUND: ATBF1 has been recently identified as a candidate prostate tumor suppressor gene. In addition to more unique mutations, two somatic mutations (shortening of a polypyrimidine tract [Poly(T)n] and a deletion beginning at codon 3381 (3381del)) were each observed in multiple prostate cancer samples and both appear to have an impact on ATBF1 gene function and expression. METHODS: We assayed two recurrent...
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