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Article

Genetic mapping of Cmv1 in the region of mouse chromosome 6 encoding the NK gene complex-associated loci Ly49 and musNKR-P1.

Genomics - 10 Jun 1995

Scalzo A A, Lyons P A, Fitzgerald N A, Forbes C A, Yokoyama W M, Shellam G R

Abstract excerpt

The Cmv1 resistance gene controls splenic replication of murine cytomegalovirus (MCMV) and confers natural killer (NK) cell-mediated resistance to otherwise lethal infection. The Cmv1 phenotypes of 13 inbred mouse strains have been assessed, and it was found that the Cmv1r resistance phenotype was restricted to the C57BL/6J and Ma/MyJ strains. We have further analyzed the linkage of Cmv1 to the NK gene complex...

Topics

Animals
Chromosome Mapping
Crosses, Genetic
Cytomegalovirus
Female
Genetic Linkage
Genetic Markers
Killer Cells, Natural
Male
Mice
Mice, Inbred Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multigene Family

Phenotype

Spleen

Virus Replication

Source

Identifiers

PMID: 7558024
DOI: 10.1006/geno.1995.1074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7558024-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Genetic mapping of Cmv1 in the region of mouse chromosome 6 encoding the NK gene complex-associated loci Ly49 and musNKR-P1.PMID 7558024Read ↗

The Cmv1 host resistance locus is closely linked to the Ly49 multigene family within the natural killer cell gene complex on mouse chromosome 6.Semantic proximity Read ↗

Localization on a physical map of the NKC-linked Cmv1 locus between Ly49b and the Prp gene cluster on mouse chromosome 6.Semantic proximity Read ↗

Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily.Semantic proximity Read ↗

High-resolution linkage map in the proximity of the host resistance locus Cmv1.Semantic proximity Read ↗

A 2-Mb YAC contig and physical map of the natural killer gene complex on mouse chromosome 6.Semantic proximity Read ↗

NK gene complex haplotype variability and host resistance alleles to murine cytomegalovirus in wild mouse populations.Semantic proximity Read ↗

Ly49h is necessary for genetic resistance to murine cytomegalovirus.Semantic proximity Read ↗

Innate immunity to cytomegalovirus: the Cmv1 locus and its role in natural killer cell function.Semantic proximity Read ↗

Use of inbred mouse strains to map recognition receptors of MCMV infected cells in the NK cell gene locus.Semantic proximity Read ↗

Structural variation of the mouse natural killer gene complex.Semantic proximity Read ↗

Ly49h-deficient C57BL/6 mice: a new mouse cytomegalovirus-susceptible model remains resistant to unrelated pathogens controlled by the NK gene complex.Semantic proximity Read ↗

Cmv1-independent antiviral role of NK cells revealed in murine cytomegalovirus-infected New Zealand White mice.Semantic proximity Read ↗

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