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Article

Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation.

Nature cell biology - 1 Sept 2012

Nittner David, Lambertz Irina, Clermont Frederic, Mestdagh Pieter, Köhler Corinna, Nielsen Søren Jensby, Jochemsen Aart, Speleman Frank, Vandesompele Jo, Dyer Michael A, Schramm Alexander, Schulte Johannes H, Marine Jean-Christophe

Abstract excerpt

Synthetic lethality is a promising strategy for specific targeting of cancer cells that carry mutations that are absent in normal cells. This approach may help overcome the challenge associated with targeting dysfunctional tumour suppressors, such as p53 and Rb (refs 1, 2). Here we show that Dice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22864477
DOI: 10.1038/ncb2556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22864477-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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