Article
Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture.
Annals of internal medicine - 20 Oct 2009
Richards J Brent, Kavvoura Fotini K, Rivadeneira Fernando, Styrkársdóttir Unnur, Estrada Karol, Halldórsson Bjarni V, Hsu Yi-Hsiang, Zillikens M Carola, Wilson Scott G, Mullin Benjamin H, Amin Najaf, Aulchenko Yurii S, Cupples L Adrienne, Deloukas Panagiotis, Demissie Serkalem, Hofman Albert, Kong Augustine, Karasik David, van Meurs Joyce B, Oostra Ben A, Pols Huibert A P, Sigurdsson Gunnar, Thorsteinsdottir Unnur, Soranzo Nicole, Williams Frances M K, Zhou Yanhua, Ralston Stuart H, Thorleifsson Gudmar, van Duijn Cornelia M, Kiel Douglas P, Stefansson Kari, Uitterlinden André G, Ioannidis John P A, Spector Tim D
Abstract excerpt
BACKGROUND: Osteoporosis is a highly heritable trait. Many candidate genes have been proposed as being involved in regulating bone mineral density (BMD). Few of these findings have been replicated in independent studies. OBJECTIVE: To assess the relationship between BMD and fracture and all common single-nucleotide polymorphisms (SNPs) in previously proposed osteoporosis candidate genes. DESIGN: Large-scale...
Topics
- Bone Density
- Female
- Fractures, Bone
- Genotype
- Humans
- Linkage Disequilibrium
- Male