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Article

Drug transport by breast cancer resistance protein

27 Sept 2010

Abstract excerpt

IMPORTANCE OF THE FIELD: The ATP-binding cassette transporter ABCG2 is a well-known major mediator of multi-drug resistance in cancers. Beyond multi-drug resistance, experimental and recent clinical studies demonstrate a role for ABCG2 as a determinant of drug pharmacokinetic, safety and efficacy profiles. AREAS COVERED IN THIS REVIEW: The clinical evidence of the role of ABCG2 in pharmacokinetics and...

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Identifiers

PMID: 20873966
DOI: 10.1517/17425255.2010.519700

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