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Structure and Function of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)

1 Sept 2010

Abstract excerpt

The human breast cancer resistance protein (BCRP/ABCG2) is the second member of the G subfamily of the large ATPbinding cassette (ABC) transporter superfamily. BCRP was initially discovered in multidrug resistant breast cancer cell lines where it confers resistance to chemotherapeutic agents such as mitoxantrone, topotecan and methotrexate by extruding these compounds out of the cell. BCRP is capable of...

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PMID: 20812902
DOI: 10.2174/138920010792927325

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