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Article

Novel checkpoint response to genotoxic stress mediated by nucleolin-replication protein a complex formation.

Molecular and cellular biology - 1 Mar 2005

Kim Kyung, Dimitrova Diana D, Carta Kristine M, Saxena Anjana, Daras Mariza, Borowiec James A

Abstract excerpt

Human replication protein A (RPA), the primary single-stranded DNA-binding protein, was previously found to be inhibited after heat shock by complex formation with nucleolin. Here we show that nucleolin-RPA complex formation is stimulated after genotoxic stresses such as treatment with camptothecin or exposure to ionizing radiation. Complex formation in vitro and in vivo requires a 63-residue...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 15743838
DOI: 10.1128/MCB.25.6.2463-2474.2005
PMCID: PMC1061594

Genes

ATM
ATR
RPA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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