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Article

Regulation of DNA Replication after Heat Shock by Replication Protein A-Nucleolin Interactions

1 Jan 2001

Abstract excerpt

Heat shock inhibits replicative DNA synthesis, but the underlying mechanism remains unknown. We investigated mechanistic aspects of this regulation in melanoma cells using a simian virus 40 (SV40)-based in vitro DNA replication assay. Heat shock (44 degrees C) caused a monotonic inhibition of cellular DNA replication following exposures for 5-90 min. SV40 DNA replication activity in extracts of similarly heated...

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PMID: 11389152
DOI: 10.1074/jbc.m100874200

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Source receipt: pubmed, retrieved 7 Sept 2026.

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