Article
The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways.
Molecular and cellular biology - 1 Apr 2002
Kabak Shara, Skaggs Brian J, Gold Michael R, Affolter Michael, West Kelly L, Foster Mark S, Siemasko Karyn, Chan Andrew C, Aebersold Ruedi, Clark Marcus R
Abstract excerpt
Following B-cell antigen receptor (BCR) ligation, the cytoplasmic domains of immunoglobulin alpha (Ig alpha) and Ig beta recruit Syk to initiate signaling cascades. The coupling of Syk to several distal substrates requires linker protein BLNK. However, the mechanism by which BLNK is recruited to the BCR is unknown. Using chimeric receptors with wild-type and mutant Ig alpha cytoplasmic tails we show that the...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Antigens, CD
- CD79 Antigens
- Carrier Proteins
- Clone Cells
- Enzyme Precursors
- Intracellular Signaling Peptides and Proteins
- Isoenzymes
- Mice