Article
A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice.
The American journal of pathology - 1 Mar 2005
Voskas Daniel, Jones Nina, Van Slyke Paul, Sturk Celina, Chang Wing, Haninec Alex, Babichev Yael Olya, Tran Jennifer, Master Zubin, Chen Stephen, Ward Nicole, Cruz Maribelle, Jones Jamie, Kerbel Robert S, Jothy Serge, Dagnino Lina, Arbiser Jack, Klement Giannoula, Dumont Daniel J
Abstract excerpt
Psoriasis is a common, persistent skin disorder characterized by recurrent erythematous lesions thought to arise as a result of inflammatory cell infiltration and activation of keratinocyte proliferation. Unscheduled angiogenic growth has also been proposed to mediate the pathogenesis of psoriasis although the cellular and molecular basis for this response remains unclear. Recently, a role for the angiopoietin...
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