Animal models of psoriasis: a critical appraisal.

Abstract excerpt

Although there is no naturally occurring disorder in laboratory animals that mimics the complex phenotype of psoriasis, a large number of spontaneous or genetically engineered mutations in rodents, immunological reconstitution approaches or xenotransplantation models have shed light on specific aspects implicated in the pathophysiology and therapy of psoriasis. Animal models have helped to elucidate functions of...

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