Article
Psoriasiform skin disease in transgenic pigs with high-copy ectopic expression of human integrins α2 and β1.
Disease models & mechanisms - 1 Jul 2017
Staunstrup Nicklas Heine, Stenderup Karin, Mortensen Sidsel, Primo Maria Nascimento, Rosada Cecilia, Steiniche Torben, Liu Ying, Li Rong, Schmidt Mette, Purup Stig, Dagnæs-Hansen Frederik, Schrøder Lisbeth Dahl, Svensson Lars, Petersen Thomas Kongstad, Callesen Henrik, Bolund Lars, Mikkelsen Jacob Giehm
Abstract excerpt
Psoriasis is a complex human-specific disease characterized by perturbed keratinocyte proliferation and a pro-inflammatory environment in the skin. Porcine skin architecture and immunity are very similar to that in humans, rendering the pig a suitable animal model for studying the biology and treatment of psoriasis. Expression of integrins, which is normally confined to the basal layer of the epidermis, is...
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