Article
Vasculotide, an Angiopoietin-1 mimetic, ameliorates several features of experimental atopic dermatitis-like disease.
BMC research notes - 28 May 2016
Bourdeau Annie, Van Slyke Paul, Kim Harold, Cruz Maribelle, Smith Tracy, Dumont Daniel J
Abstract excerpt
BACKGROUND: Earlier studies by our group have demonstrated that a transgenic animal engineered to express Tie2 under the control of the Tie2 promoter produced animals with a scaly skin phenotype that recapitulated many of the hallmarks of atopic dermatitis (AT-Derm). To test the hypothesis that this model of AT-Derm is driven by dysregulated Tie2-signalling, we have bred AT-Derm transgenic (TG) animals with...
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