Article
Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis.
PloS one - 4 Apr 2011
Swindell William R, Johnston Andrew, Carbajal Steve, Han Gangwen, Wohn Christian, Lu Jun, Xing Xianying, Nair Rajan P, Voorhees John J, Elder James T, Wang Xiao-Jing, Sano Shigetoshi, Prens Errol P, DiGiovanni John, Pittelkow Mark R, Ward Nicole L, Gudjonsson Johann E
Abstract excerpt
Development of a suitable mouse model would facilitate the investigation of pathomechanisms underlying human psoriasis and would also assist in development of therapeutic treatments. However, while many psoriasis mouse models have been proposed, no single model recapitulates all features of the human disease, and standardized validation criteria for psoriasis mouse models have not been widely applied. In this...
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