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Article

Keratinocyte but not endothelial cell-specific overexpression of Tie2 leads to the development of psoriasis.

The American journal of pathology - 1 Apr 2009

Wolfram Julie A, Diaconu Doina, Hatala Denise A, Rastegar Jessica, Knutsen Dorothy A, Lowther Abigail, Askew David, Gilliam Anita C, McCormick Thomas S, Ward Nicole L

Abstract excerpt

Psoriasis is initiated and maintained through a multifaceted interplay between keratinocytes, blood vessels, gene expression, and the immune system. One previous psoriasis model demonstrated that overexpression of the angiopoietin receptor Tie2 in endothelial cells and keratinocytes led to the development of a psoriasiform phenotype; however, the etiological significance of overexpression in each cell type alone...

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Topics

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Share to Endothelial Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neovascularization, Pathologic

Share to Oligonucleotide Array Sequence Analysis

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Share to Receptor, TIE-2

Share to Vascular Endothelial Growth Factor A

Source

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Identifiers

PMID: 19342373
DOI: 10.2353/ajpath.2009.080858
PMCID: PMC2671375

Genes

CD4
S100A8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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