Article
Phenotypic characterization of the human myeloma cell growth fraction.
Blood - 15 Jun 2005
Robillard Nelly, Pellat-Deceunynck Catherine, Bataille Régis
Abstract excerpt
In this study we quantified the proliferation rate of normal and malignant plasma cells (PCs) by ex vivo incorporation of 5-bromo-2'-deoxyuridine (BrdU; labeling index, LI) using flow cytometry. We show that all bone marrow PCs, either normal or malignant, include a subset of proliferating PCs present within the CD45(bright) fraction. Indeed, medullary normal and malignant PCs were always heterogeneous for CD45...
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