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Article

The phenotypic plasticity of myeloma plasma cells as expressed by dedifferentiation into an immature, resilient, and apoptosis-resistant phenotype.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2005

Yaccoby Shmuel

Abstract excerpt

PURPOSE: We previously showed the ability of osteoclasts to support myeloma plasma cell survival and proliferation in vivo and ex vivo. The aim of the current study was to investigate osteoclast-induced phenotypic changes associated with long-term survival of myeloma cells in coculture. EXPERIMENTAL DESIGN: CD138-selected myeloma plasma cells from 16 patients were cocultured with human osteoclasts for up to 20...

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Identifiers

PMID: 16278377
DOI: 10.1158/1078-0432.CCR-05-0523
PMCID: PMC1592552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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