Article
Differentiation stage of myeloma plasma cells: biological and clinical significance.
Leukemia - 1 Feb 2017
Paiva B, Puig N, Cedena M T, de Jong B G, Ruiz Y, Rapado I, Martinez-Lopez J, Cordon L, Alignani D, Delgado J A, van Zelm M C, Van Dongen J J M, Pascual M, Agirre X, Prosper F, Martín-Subero J I, Vidriales M-B, Gutierrez N C, Hernandez M T, Oriol A, Echeveste M A, Gonzalez Y, Johnson S K, Epstein J, Barlogie B, Morgan G J, Orfao A, Blade J, Mateos M V, Lahuerta J J, San-Miguel J F
Abstract excerpt
The notion that plasma cells (PCs) are terminally differentiated has prevented intensive research in multiple myeloma (MM) about their phenotypic plasticity and differentiation. Here, we demonstrated in healthy individuals (n=20) that the CD19-CD81 expression axis identifies three bone marrow (BM)PC subsets with distinct age-prevalence, proliferation, replication-history, immunoglobulin-production, and phenotype,...
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